Bioequivalence Study of Modified-Release Gliclazide Tablets in Healthy Volunteers
نویسندگان
چکیده
منابع مشابه
Bioequivalence Study of Modified-Release Gliclazide Tablets in Healthy Volunteers
This study was aimed to investigate bioequivalence of modified-release 30 mg gliclazide tablets in 18 healthy Thai volunteers. A test product, Glycon MR (Siam Bheasach, TH), was compared with a reference product, Diamicron MR (Servier, France). The study was performed under a single-dose, two-treatment, two-period, and two-sequence crossover design in fasted and fed conditions with a washout pe...
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The objective of this study was to investigate the bioequivalence of two formulations of 5 mg donepezil HCL tablets: Tonizep as the test and Aricept as the reference. The two products were administered as a single oral dose according to a randomized two-phase crossover with a 3-week washout period in 20 healthy Thai Male volunteers. After drug administration, serial blood samples were collected...
متن کاملPharmacokinetics and Pharmacodynamics of Gliclazide from Immediate and Modified Release Formulation Tablets in Rats
The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...
متن کاملPharmacokinetics and Pharmacodynamics of Gliclazide from Immediate and Modified Release Formulation Tablets in Rats
The objective of the study was to compare pharmacokinetic and pharmacodynamic parameters of gliclazide after administration of immediate (IR) and modified release (MR) tablets. The experiment included rats with both normoglyceamia and streptozocin (STZ)-induced hyperglyceamia. Several MR formulations were designed and in vitro drug release profile was assessed by a dissolution test. For the fur...
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Aim Chlorzoxazone is analgesic muscle relaxants. On clinic it is used to treat painful muscle spasms. The aim of the study is to investigate human bioequivalence of chlorzoxazone tablets. Methods Eight healthy male volunteers were recruited. They were divided to two groups randomly. A HPLC was used to determine the blood concentrations of chlorzoxazone. .In the morning 400mg of reference drug o...
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ژورنال
عنوان ژورنال: ISRN Pharmacology
سال: 2012
ISSN: 2090-5173
DOI: 10.5402/2012/375134